I was flying on autopilot with a small load of Caldari Navy Heavy Assault Missile Launchers onboard. Nothing unusual, I fly on auto with more valuable cargoes than that
My route was taking me through Litiura an 0.5 sec system I'd noted was often solo camped by a destroyer. He'd taken shots at me a few times before but his efforts were quite laughable. He'd never come close to killing me, not even when I was afk. So I wasn't too worried about it but I was planning on going manual for the jump through Litiura just to be safe.
Then the phone rang... Since it was work related I had to answer. By the time I got back I was in Litiura, the camper was shooting at me and had me a sliver into hull already. If I'd gotten back just a few seconds later I would have easily escaped but I was too late and he got me.
According to the combat report I lost 315 million ISK, however that's assuming the missile launchers are worth over 300 million when in fact I only paid 175 million for them.
With the cost of the ship + rigs (I got the rest of the fittings back) I actually only lost about 176 million though I did also lose the opportunity to make 130 - 140 million profit on the cargo. Barely worth taking the time to pick them up, I almost left them for the next day.
Whether you count it as 176 million or 315 million, it's still just a small loss for me and won't cause me to change my routine. Considering I've only been ganked in hisec twice (in total on all my characters) in over a year and didn't lose very much either time (the first was for about 75 million) I'm not at all worried about it. I make more in a single day than I've lost to hisec ganks the whole time I've been playing Eve (over a year now). That's an acceptable risk I'm more than willing to take.