I finally lost my first Blockade Runner in high sec while on autopilot.
It was empty! =)
The funny thing is it wasn't in one of the usual places gankers like to camp like Uedama, Litiura, or the Aufay, Balle, Deltole chain. In fact it wasn't even in an 0.5 system, it was higher sec status than that. I'm surprised he managed to live for the 18 seconds it took him to blow up my ship before Concord arrived and killed him.
It might have been someone intentionally targeting me, hoping to win the BR lottery and cash in a big load. The character's name makes it pretty obvious to anyone who knows much about me that it must be one of my alts.
If that's the case I'll have to stop transporting big loads on that particular character. But that's ok, it happened to a character based out of Jita and I have plenty of other alts with less obvious names there.